Lightroom :: 4.1 Corrupted And Slow Catalogs

I know there are lots of LR4 performance issues floating around, but I havent been having the normal develope modue issues.  My issues are more related to general catalog loading and responsivene
 
Basically my catalogs tend to slow down drastically over a couple days of useage until they are pretty much useless.  When I first import in a catalog they seem to be pretty quick, previews load correctly and when i go to develope it loads up in a couple seconds.  Give it a couple days or a few hours of useage though and all of a sudden the catalog will refuse to load images that were not already in cache and trying to open an image will cause the LR to come to a hault and just sit there.  If you leave it for a few hours it will eventually load them up usually.  I have lost a couple catalogs to this issue.  Closing the program and reopening usually results in LR not opening at all.  Windows wont even let me kill LR through taskmanager sometimes.  I usually have to log out and log back in, but sometimes it will still say the catalog is currently in use.
 
Running window7 64bit, i7 2700k, 16bg ram, intel 320 ssd (os, LR, and LR raw cache 8gb), nvidia 240gtx, images drive is a seagate 7200k 2TB drive.  Raw files are from a d800 and d700.  Seems to be more issues with the d800 files though.
 
I honestly have gotten to the point where I have to back up my catalogs as jpegs daily and often times to complete a wedding I need to use 2-3 different catalogs.  LR3 had no issues at all on the same system.
 
Consider a full OS wipe and restore, or trying to convert to DNGs before editing.