Illustrator :: How To Make Actual Comic Panels

is there a way to make it so everything that appears on the artboard is hidden/invisible, and have it so my vector shapes/images only appear inside rectangle/panels?
 
As of now, if I am to create a comic using the pen tool, and some parts of the vector are outside the rectangles (panels) I made, I would either have to use the knife tool to cut off the vectors outside, or hide the vectors outside the panels with white rectangles (since my artboard is white).