Photoshop :: Color Not Good In CS5?

my setup is: Pentax K20/80-200,2.8 Star ED, dual studio flashes with semitransparent white umbrellas, X-rite color proofing card, CS5, Syncmaster 214T with Spyder2 for calibration and Epson R2400 with all the proper ICC profiles..trying to repro an artwork with many nuances, particulary blue, red and yellow, the red one will show properly. The red gets smeary and too red.

The artwork has a little more of blue in it but that does not show up in the print, just on screen. The difference from screen to paper is too big for my taste (calibrated the day before). I've recently repaired the monitor with better quality capacitors to enhance performance.

I use glossy Epson paper.  Also the blue seems to bleed when printed. Resolution of picture is 360dpi as recommended by Epson. I use "keep sharp edges"when enlarging it from the original 240dpi. This has the effect of retaining the colors at least on screen. Sharp image = more pure colors.